Samter's Triad to Aspirin-Exacerbated Respiratory Disease: Historical Perspective and Current Clinical Practice

ORL Head Neck Nurs. 2015 Autumn;33(4):14-8.


Aspirin-exacerbated respiratory disease (AERD), formerly known as Samter's Triad, is a syndrome of airway inflammation characterized by rhinosinusitis with polyposis, asthma, and nonsteroidal anti-inflammatory drug (NSAID) intolerance. Approximately 7% of patients with asthma will also have AERD making prompt identification, diagnosis, and management of this syndrome important to controlling the disease progression. This paper will provide a brief biographical background on Max Samter, MD, followed by an epidemiologic overview, clinical presentation and diagnosis, and management strategies, which highlight patient counseling and educational needs.

Publication types

  • Biography
  • Case Reports
  • Historical Article

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspirin / adverse effects*
  • Asthma, Aspirin-Induced / diagnosis
  • Asthma, Aspirin-Induced / etiology*
  • Asthma, Aspirin-Induced / therapy
  • Drug Hypersensitivity
  • Female
  • Germany
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Male
  • Middle Aged
  • Nasal Polyps / diagnosis
  • Nasal Polyps / etiology*
  • Nasal Polyps / therapy
  • Sinusitis / diagnosis
  • Sinusitis / etiology*
  • Sinusitis / therapy


  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin

Personal name as subject

  • Max Samter