Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 27 (2), 105-117

Mitochondrial Dynamics and Metabolic Regulation

Affiliations
Review

Mitochondrial Dynamics and Metabolic Regulation

Timothy Wai et al. Trends Endocrinol Metab.

Abstract

Mitochondrial morphology varies tremendously across cell types and tissues, changing rapidly in response to external insults and metabolic cues, such as nutrient status. The many functions of mitochondria have been intimately linked to their morphology, which is shaped by ongoing events of fusion and fission of outer and inner membranes (OM and IM). Unopposed fission causes mitochondrial fragmentation, which is generally associated with metabolic dysfunction and disease. Unopposed fusion results in a hyperfused network and serves to counteract metabolic insults, preserve cellular integrity, and protect against autophagy. Here, we review the ways in which metabolic alterations convey changes in mitochondrial morphology and how disruption of mitochondrial morphology impacts cellular and organismal metabolism.

Keywords: fission; fusion; metabolism; mitochondria; mitochondrial dynamics.

Similar articles

See all similar articles

Cited by 182 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback