Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

J Autism Dev Disord. 2016 Apr;46(4):1455-63. doi: 10.1007/s10803-015-2694-0.

Abstract

15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford-Binet) are suitable for assessment of cognitive function in affected individuals. These three tests were administered to ten individuals with 15q13.3 microdeletion syndrome (14-18 years of age), and the results were analyzed to determine feasibility of use, potential for improvement, and internal consistency. It was determined that the KiTAP, CogState, and Stanford-Binet are valid tests of cognitive function in 15q13.3 microdeletion patients. Therefore, these tests may be considered for use as objective outcome measures in future clinical trials, assessing change in cognitive function over a period of pharmacological treatment.

Keywords: Autism; Cognitive function; Cognitive tests; Intellectual disability; Neuropsychiatric disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Autistic Disorder / genetics*
  • Autistic Disorder / psychology
  • Chromosome Deletion
  • Chromosome Disorders / psychology*
  • Chromosomes, Human, Pair 15
  • Cognition / physiology*
  • Female
  • Humans
  • Intellectual Disability / psychology*
  • Male
  • Neuropsychological Tests
  • Seizures / psychology*

Supplementary concepts

  • Chromosome 15q13.3 Microdeletion Syndrome