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. 2016 Apr 30;22(2):304-9.
doi: 10.5056/jnm15131.

Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats

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Free PMC article

Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats

Je Wook Kang et al. J Neurogastroenterol Motil. .
Free PMC article

Abstract

Background/aims: DA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrum in the normal and clonidine-induced hypomotility in an in vivo animal model.

Methods: A strain gauge force transducer was sutured on the gastric antrum to measure the contractile activity in rats. A total of 28 rats were subclassified into the 4 groups: (1) the placebo group, (2) the DA-9701 group, (3) the placebo group in the clonidine-pretreated rats, and (4) the DA-9701 group in the clonidine-pretreated rats. After the basal recording, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. In the clonidinepretreated rats, either placebo or DA-9701 was administered. Contractile signals were measured after the administration and after a meal.

Results: Oral administration of DA-9701 did not significantly alter the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the placebo group. The administration of clonidine decreased the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the administration of placebo. This reduction of the antral motility by the administration of clonidine was not observed in the clonidine-pretreated DA-9701 group. The percentage of the motility index in the postprandial period was significantly greater in the clonidine-pretreated DA-9701 group, compared with the clonidine-pretreated placebo group.

Conclusions: DA-9701 improves the hypomotility of the gastric antrum induced by clonidine, suggesting its gastroprokinetic effect in the pathologic condition.

Keywords: Antrum; DA-9701; Motility; Prokinetic.

Figures

Figure 1
Figure 1
Study protocols. (A) After the basal recording for 20 minutes, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 (3 mg/kg) was administered orally, and then the standardized liquid meal was administered through the feeding tube. (B) After the basal recording for 20 minutes, clonidine hydrochloride (clonidine) at a dose of 100 μg/kg was subcutaneously administered. Subsequently, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 was administered orally, and then the standardized liquid meal was administered through the feeding tube.
Figure 2
Figure 2
Effects of placebo or DA-9701 on normal motility and hypomotility of the gastric antrum. Compared with the placebo group (A), the motility index of the gastric antrum was not significantly changed after the administration of DA-9701 (B), both in the preprandial and postprandial periods. In the clonidine-pretreated placebo group, the motility index of the gastric antrum was significantly reduced, both in the preprandial and postprandial periods (C), but this hypomotility was not observed in the clonidine-pretreated DA-9701 group (D).

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