The nature of the lymphocytes surrounding Reed-Sternberg cells in nodular lymphocyte predominance and in other types of Hodgkin's disease

Am J Pathol. 1989 Aug;135(2):351-7.

Abstract

The lymphocytes surrounding Reed-Sternberg cells may play an important role in the pathogenesis of Hodgkin's disease. In this study, T cells in different subtypes of Hodgkin's disease were analyzed in situ by an immunoperoxidase method employing a panel of antibodies, including several paraffin tissue-reactive monoclonal antibodies. The T cells in Hodgkin's disease-involved tissues were found to be activated CD4-positive T cells that are UCHL1+ and CD45R-. This immunophenotype is compatible with an activated helper-inducer memory T cell population. The T cells in the nodular lymphocyte predominance subtype were found to have additional positivity for Leu 7, indicating a subpopulation of CD4+ T cells, normally confined to the light zone of germinal centers of secondary follicles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • Female
  • Frozen Sections
  • Histological Techniques
  • Hodgkin Disease / classification
  • Hodgkin Disease / immunology
  • Hodgkin Disease / pathology*
  • Humans
  • Lymph Nodes / immunology
  • Lymph Nodes / pathology*
  • Male
  • Middle Aged
  • Phenotype
  • T-Lymphocytes / immunology
  • T-Lymphocytes / pathology*

Substances

  • Antigens, Differentiation, T-Lymphocyte