Alterations of neocortico-limbic association fibers and correlation with diet in prediabetes diagnosed by impaired fasting glucose

J Magn Reson Imaging. 2016 Jun;43(6):1500-6. doi: 10.1002/jmri.25127. Epub 2016 Jan 12.

Abstract

Purpose: To assess the existence of alterations in the micro-integrity of the fasciculus in prediabetic subjects. The issue of micro-integrity in white matter tracts has not been adequately addressed in prediabetes.

Materials and methods: Sixty-four prediabetic subjects and 54 controls were enrolled. All participants completed 24-hour diet records and 3-day diet records and received diffusion tensor imaging at 3T. The data for white matter micro-integrity were analyzed and compared between prediabetic subjects and controls with age and gender as covariates. In addition, voxel-wise regression between white matter micro-integrity, diet, and preprandial glucose levels were used to explore the relationship between white matter micro-integrity and diet or serum glucose levels.

Results: We found that prediabetic subjects had significant reductions in the micro-integrity of bilateral anterior thalamic radiation, left inferior longitudinal fasciculus, and left superior longitudinal fasciculus (corrected P < 0.05). In addition, total carbohydrate intake amount and preprandial serum glucose levels were negatively correlated with the micro-integrity in the left inferior longitudinal fasciculus and left anterior thalamic radiation (r: -0.47, corrected P < 0.05).

Conclusion: Restrictive alterations in the white matter micro-integrity of the anterior thalamic radiation and inferior and superior longitudinal fasciculi might represent the initial "hot spots" for white matter tract alterations, which might play a role in the development of prediabetes. J. Magn. Reson. Imaging 2016;43:1500-1506.

Keywords: anterior thalamic radiation; inferior longitudinal fasciculus; prediabetes; superior longitudinal fasciculus; white matter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Glucose / metabolism*
  • Diet / methods
  • Diffusion Tensor Imaging / methods*
  • Fasting
  • Female
  • Glucose Tolerance Test
  • Humans
  • Limbic System / diagnostic imaging
  • Limbic System / pathology*
  • Male
  • Neocortex / diagnostic imaging
  • Neocortex / pathology*
  • Prediabetic State / metabolism*
  • Prediabetic State / pathology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistics as Topic
  • White Matter / diagnostic imaging
  • White Matter / pathology*

Substances

  • Blood Glucose