Abstract
Involvement of Escherichia coli penicillin-binding proteins (PBPs) in induction of the cloned ampC Citrobacter freundii beta-lactamase by 6-aminopenicillanic acid was investigated. The enzyme was not inducible at 42 degrees C in a mutant thermosensitive for expression of PBP 2. The results imply that PBP 2 is involved in the process leading to induction of ampC.
MeSH terms
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Acyltransferases / metabolism*
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Bacterial Proteins*
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Carrier Proteins*
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Chromosomes, Bacterial
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Citrobacter / enzymology*
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Citrobacter / genetics
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Enzyme Induction / drug effects
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Genes, Bacterial
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Hexosyltransferases / metabolism*
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Multienzyme Complexes / metabolism*
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Muramoylpentapeptide Carboxypeptidase*
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Mutation
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Penicillin-Binding Proteins
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Peptidyl Transferases / metabolism*
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beta-Lactamases / biosynthesis*
Substances
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Bacterial Proteins
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Carrier Proteins
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Multienzyme Complexes
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Penicillin-Binding Proteins
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Acyltransferases
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Peptidyl Transferases
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Hexosyltransferases
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Muramoylpentapeptide Carboxypeptidase
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beta-Lactamases