Penicillin-binding protein 2 is required for induction of the Citrobacter freundii class I chromosomal beta-lactamase in Escherichia coli

Antimicrob Agents Chemother. 1989 Jul;33(7):1116-7. doi: 10.1128/AAC.33.7.1116.

Abstract

Involvement of Escherichia coli penicillin-binding proteins (PBPs) in induction of the cloned ampC Citrobacter freundii beta-lactamase by 6-aminopenicillanic acid was investigated. The enzyme was not inducible at 42 degrees C in a mutant thermosensitive for expression of PBP 2. The results imply that PBP 2 is involved in the process leading to induction of ampC.

MeSH terms

  • Acyltransferases / metabolism*
  • Bacterial Proteins*
  • Carrier Proteins*
  • Chromosomes, Bacterial
  • Citrobacter / enzymology*
  • Citrobacter / genetics
  • Enzyme Induction / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / genetics
  • Genes, Bacterial
  • Hexosyltransferases / metabolism*
  • Multienzyme Complexes / metabolism*
  • Muramoylpentapeptide Carboxypeptidase*
  • Mutation
  • Penicillin-Binding Proteins
  • Peptidyl Transferases / metabolism*
  • beta-Lactamases / biosynthesis*

Substances

  • Bacterial Proteins
  • Carrier Proteins
  • Multienzyme Complexes
  • Penicillin-Binding Proteins
  • Acyltransferases
  • Peptidyl Transferases
  • Hexosyltransferases
  • Muramoylpentapeptide Carboxypeptidase
  • beta-Lactamases