Support for the Microgenderome: Associations in a Human Clinical Population

Sci Rep. 2016 Jan 13;6:19171. doi: 10.1038/srep19171.

Abstract

The 'microgenderome' provides a paradigm shift that highlights the role of sex differences in the host-microbiota interaction relevant for autoimmune and neuro-immune conditions. Analysis of cross-sectional self-report and faecal microbial data from 274 patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) suggests that commensal gut microorganisms may play both protective and deleterious roles in symptom expression. Results revealed significant sex-specific interactions between Firmicutes (Clostridium, Streptococcus, Lactobacillus and Enterococcus) and ME/CFS symptoms (including neurological, immune and mood symptoms), regardless of compositional similarity in microbial levels across the sexes. Extending animal studies, we provide support for the microgenderome in a human clinical population. Applied and mechanistic research needs to consider sex-interactions when examining the composition and function of human microbiota.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteria / classification
  • Biodiversity
  • Child
  • Fatigue Syndrome, Chronic / diagnosis
  • Fatigue Syndrome, Chronic / microbiology
  • Female
  • Gastrointestinal Microbiome
  • Humans
  • Male
  • Metagenomics* / methods
  • Microbiota*
  • Middle Aged
  • Sex Factors
  • Young Adult