Effect of endothelin-1 on release of arginine-vasopressin from perifused rat hypothalamus

Biochem Biophys Res Commun. 1989 Sep 29;163(3):1332-7. doi: 10.1016/0006-291x(89)91124-8.

Abstract

Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocked in the presence of nicardipine. Our results suggest a possible involvement of ET in the regulation of AVP release.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine Vasopressin / metabolism*
  • Endothelins
  • Endothelium, Vascular / physiology
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism*
  • In Vitro Techniques
  • Kinetics
  • Male
  • Peptides / pharmacology*
  • Perfusion
  • Rats
  • Rats, Inbred Strains

Substances

  • Endothelins
  • Peptides
  • Arginine Vasopressin