Successful treatment of severe refractory lupus hepatitis with mycophenolate mofetil

Lupus. 2016 Apr;25(5):543-6. doi: 10.1177/0961203315625118. Epub 2016 Jan 12.

Abstract

Systemic lupus erythematosus-related hepatitis, known as lupus hepatitis, is a rare manifestation of systemic lupus erythematosus, and is usually subclinical with mild abnormalities of serum liver enzymes. While cases with clinically significant and refractory lupus hepatitis are uncommon, treatment options for lupus hepatitis are to be established. Here, we report the case of a 45-year-old man with progressive lupus hepatitis accompanied by autoimmune haemolytic anaemia. Lupus hepatitis of this patient was refractory to tacrolimus, azathioprine and cyclophosphamide, but was successfully treated by mycophenolate mofetil. Mycophenolate mofetil might be an effective therapeutic option for refractory lupus hepatitis.

Keywords: Lupus hepatitis; mycophenolate mofetil; systemic lupus erythematosus.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic, Autoimmune / diagnosis
  • Anemia, Hemolytic, Autoimmune / drug therapy*
  • Anemia, Hemolytic, Autoimmune / immunology
  • Biopsy
  • Diagnosis, Differential
  • Drug Resistance
  • Drug Substitution
  • Hepatitis / diagnosis
  • Hepatitis / drug therapy*
  • Hepatitis / immunology
  • Hepatitis, Autoimmune / diagnosis
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Liver Function Tests
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Erythematosus, Systemic / drug therapy*
  • Lupus Erythematosus, Systemic / immunology
  • Male
  • Middle Aged
  • Mycophenolic Acid / therapeutic use*
  • Predictive Value of Tests
  • Remission Induction
  • Treatment Outcome

Substances

  • Immunosuppressive Agents
  • Mycophenolic Acid