The contribution of HLA to rheumatoid arthritis

Clin Genet. 1989 Sep;36(3):178-82. doi: 10.1111/j.1399-0004.1989.tb03185.x.


The contribution of genes within the major histocompatibility complex to rheumatoid arthritis has been calculated (Rotter & Landaw 1984). Separate data from hospital- and population-based studies of monozygotic twin concordance rates and sibling recurrence risks have been used, along with material from published haplotype-sharing studies. Using either source of information gives the same result, a contribution of 37%.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / genetics*
  • Diseases in Twins*
  • Family
  • HLA Antigens / genetics*
  • Humans
  • Twins, Monozygotic


  • HLA Antigens