Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

J Virol. 2016 Jan 13;90(7):3789-93. doi: 10.1128/JVI.03060-15.


A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Line
  • Epitopes / genetics
  • Gene Expression
  • Genomic Instability
  • Hemagglutinin Glycoproteins, Influenza Virus / biosynthesis*
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Humans
  • Influenza A virus / genetics*
  • Influenza A virus / growth & development
  • Influenza A virus / physiology
  • Influenza Vaccines / genetics
  • Neutralization Tests
  • Recombinant Proteins / biosynthesis*
  • Recombinant Proteins / genetics
  • Viral Plaque Assay
  • Virus Replication


  • Epitopes
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Influenza Vaccines
  • Recombinant Proteins