Metformin Joins Forces with Microbes

Cell Host Microbe. 2016 Jan 13;19(1):1-3. doi: 10.1016/j.chom.2015.12.012.


The gut microbiota is a key player regulating human physiology and can adjust its structure and metabolic activity in response to host health. A recent Nature paper by Forslund et al. (2015) reveals that microbiota adaptation to metformin treatment are responsible for the drug's therapeutic effects against type 2 diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Diabetes Mellitus, Type 2 / microbiology*
  • Female
  • Gastrointestinal Microbiome / drug effects*
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Male
  • Metformin / pharmacology*


  • Metformin