Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes

Cell Metab. 2016 Jan 12;23(1):10-2. doi: 10.1016/j.cmet.2015.12.012.


Type 2 diabetes (T2D) is associated with dysbiosis of the gut microbiota, though diabetes treatment regimens, including metformin, may confound the results. Forslund et al. (2015) identify distinct disease and drug signatures and highlight the importance of adjusting for treatment when investigating how T2D influences the human gut microbiome.

Publication types

  • Comment

MeSH terms

  • Diabetes Mellitus, Type 2 / microbiology*
  • Female
  • Gastrointestinal Microbiome / drug effects*
  • Gastrointestinal Microbiome / physiology*
  • Humans
  • Male
  • Metformin / pharmacology*


  • Metformin