Understanding the immunogenicity and antigenicity of nanomaterials: Past, present and future

Toxicol Appl Pharmacol. 2016 May 15;299:70-7. doi: 10.1016/j.taap.2016.01.005. Epub 2016 Jan 7.


Nanoparticle immunogenicity and antigenicity have been under investigation for many years. During the past decade, significant progress has been made in understanding what makes a nanoparticle immunogenic, how immune cells respond to nanoparticles, what consequences of nanoparticle-specific antibody formation exist and how they challenge the application of nanoparticles for drug delivery. Moreover, it has been recognized that accidental contamination of therapeutic protein formulations with nanosized particulate materials may contribute to the immunogenicity of this type of biotechnology products. While the immunological properties of engineered nanomaterials and their application as vaccine carriers and adjuvants have been given substantial consideration in the current literature, little attention has been paid to nanoparticle immuno- and antigenicity. To fill in this gap, we herein provide an overview of this subject to highlight the current state of the field, review past and present research, and discuss future research directions.

Keywords: Anaphylaxis; Antibody; Antigenicity; Cytokines; Immunogenicity; Nanoparticles; Phagocytosis; Preclinical.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / toxicity
  • Animals
  • Antigenic Modulation / drug effects
  • Antigenic Modulation / immunology*
  • Comprehension*
  • Drug Carriers / administration & dosage
  • Drug Carriers / toxicity
  • Drug Delivery Systems / adverse effects
  • Drug Delivery Systems / methods
  • Forecasting
  • Humans
  • Immunity, Cellular / drug effects
  • Immunity, Cellular / immunology*
  • Immunogenetic Phenomena / drug effects
  • Immunogenetic Phenomena / immunology*
  • Nanostructures / administration & dosage
  • Nanostructures / toxicity*


  • Adjuvants, Immunologic
  • Drug Carriers