Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination

Yi-Nan Zhang; Wilson Poon; Anthony J Tavares; Ian D McGilvray; Warren C W Chan

doi:10.1016/j.jconrel.2016.01.020

Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination

J Control Release. 2016 Oct 28:240:332-348. doi: 10.1016/j.jconrel.2016.01.020. Epub 2016 Jan 13.

Authors

Yi-Nan Zhang¹, Wilson Poon¹, Anthony J Tavares¹, Ian D McGilvray², Warren C W Chan³

Affiliations

¹ Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada.
² Multi Organ Transport Program, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada; Toronto General Research Institute, University Health Network, 585 University Avenue, Toronto, ON M5G 2N2, Canada.
³ Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Chemistry, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Chemical Engineering & Applied Chemistry, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada; Department of Materials Science and Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. Electronic address: warren.chan@utoronto.ca.

PMID: 26774224
DOI: 10.1016/j.jconrel.2016.01.020

Abstract

30-99% of administered nanoparticles will accumulate and sequester in the liver after administration into the body. This results in reduced delivery to the targeted diseased tissue and potentially leads to increased toxicity at the hepatic cellular level. This review article focuses on the inter- and intra-cellular interaction between nanoparticles and hepatic cells, the elimination mechanism of nanoparticles through the hepatobiliary system, and current strategies to manipulate liver sequestration. The ability to solve the "nanoparticle-liver" interaction is critical to the clinical translation of nanotechnology for diagnosing and treating cancer, diabetes, cardiovascular disorders, and other diseases.

Keywords: Hepatobiliary clearance; Liver; Macrophage; Nanoparticle.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biliary Tract / drug effects
Biliary Tract / metabolism*
Hepatobiliary Elimination
Humans
Kupffer Cells / drug effects
Kupffer Cells / metabolism*
Liver / drug effects
Liver / metabolism*
Nanoparticles / chemistry
Nanoparticles / metabolism*
Nanoparticles / toxicity
Surface Properties

Grants and funding

MOP-130143/CIHR/Canada