Antioxidant 21-aminosteroid "U-74389G" ameliorates the short-time effect of hypoxia-reoxygenation on the platelet count in rats

Folia Med Cracov. 2015;55(1):25-34.

Abstract

Aim: The aim of this experimental study was to examine the effect of the antioxidant drug "U-74389G", on rat model and particularly in a hypoxia-reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule were studied hematologically using blood mean platelet count. Results were that U-74389G administration interacted or not with reoxygenation time decreased the platelet count by 6.12% ± 3.58% (p = 0.0857) and 12.83% ± 5.79% (p = 0.0303) respectively.

Conclusions: U-74389G administration interacted or not with reoxygenation time decreases the platelet count within short-term time of 2 hours by different significance levels.

Keywords: U-74389G; hypoxia; platelet count; reoxygenation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Disease Models, Animal
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology*
  • Hypoxia / blood
  • Hypoxia / drug therapy*
  • Platelet Count
  • Pregnatrienes / administration & dosage
  • Pregnatrienes / pharmacology*
  • Rats
  • Rats, Wistar
  • Reperfusion Injury / blood
  • Reperfusion Injury / drug therapy*

Substances

  • Antioxidants
  • Free Radical Scavengers
  • Pregnatrienes
  • U 74389F