Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

Cytokine Growth Factor Rev. 2016 Apr;28:21-9. doi: 10.1016/j.cytogfr.2015.12.004. Epub 2016 Jan 2.

Abstract

NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers.

Keywords: Cancer; Curcumin; Inflammation; NF-κB.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / pharmacology
  • Carcinogenesis / drug effects
  • Curcumin / pharmacology*
  • Humans
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism
  • Neoplasm Metastasis
  • Neoplasms / blood supply
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Neovascularization, Physiologic / drug effects
  • Signal Transduction / drug effects

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • NF-kappa B
  • Curcumin