Curcumin liposomes prepared with milk fat globule membrane phospholipids and soybean lecithin

J Dairy Sci. 2016 Mar;99(3):1780-1790. doi: 10.3168/jds.2015-10391. Epub 2016 Jan 13.


Using thin film ultrasonic dispersion method, the curcumin liposomes were prepared with milk fat globule membrane (MFGM) phospholipids and soybean lecithins, respectively, to compare the characteristics and stability of the 2 curcumin liposomes. The processing parameters of curcumin liposomes were investigated to evaluate their effects on the encapsulation efficiency. Curcumin liposomes were characterized in terms of size distribution, ζ-potential, and in vitro release behavior, and then their storage stability under various conditions was evaluated. The curcumin liposomes prepared with MFGM phospholipids had an encapsulation efficiency of about 74%, an average particle size of 212.3 nm, and a ζ-potential of -48.60 mV. The MFGM liposomes showed higher encapsulation efficiency, smaller particle size, higher absolute value of ζ-potential, and slower in vitro release than soybean liposomes. The retention rate of liposomal curcumin was significantly higher than that of free curcumin. The stability of the 2 liposomes under different pH was almost the same, but MFGM liposomes displayed a slightly higher stability than soybean liposomes under the conditions of Fe(3+), light, temperature, oxygen, and relative humidity. In conclusion, MFGM phospholipids have potential advantages in the manufacture of curcumin liposomes used in food systems.

Keywords: curcumin; liposome; milk fat globule membrane; phospholipid; soybean lecithin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Curcumin / administration & dosage*
  • Curcumin / chemistry
  • Curcumin / radiation effects
  • Drug Stability
  • Food Technology
  • Glycolipids / chemistry
  • Glycoproteins / chemistry
  • Hydrogen-Ion Concentration
  • Lecithins / chemistry*
  • Light
  • Lipid Droplets
  • Liposomes
  • Particle Size
  • Phospholipids / chemistry*
  • Soybeans / chemistry
  • Temperature


  • Glycolipids
  • Glycoproteins
  • Lecithins
  • Liposomes
  • Phospholipids
  • milk fat globule
  • Curcumin