Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models

Sci Rep. 2016 Jan 18;6:19399. doi: 10.1038/srep19399.


Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Colon / immunology
  • Colon / metabolism
  • Colon / microbiology
  • Disease Models, Animal
  • Faecalibacterium prausnitzii / physiology*
  • Intestinal Mucosa*
  • Irritable Bowel Syndrome / etiology*
  • Irritable Bowel Syndrome / metabolism
  • Irritable Bowel Syndrome / microbiology
  • Male
  • Maternal Deprivation
  • Mice
  • Permeability
  • Stress, Physiological