Fight, Flight, or Freeze? The Answer May Depend on Your Sex

Trends Neurosci. 2016 Feb;39(2):51-53. doi: 10.1016/j.tins.2015.12.010. Epub 2016 Jan 6.


Pavlovian fear conditioning is one of the most common and well-understood methods for studying fear learning. However, research is predominantly performed in males. Recently, in a classical Pavlovian fear conditioning paradigm, Gruene and colleagues described an active conditioned fear response ('darting') prevalent in female rats that better maintain an extinction memory.

Keywords: escape; fear conditioning; females; sex differences.

Publication types

  • Comment

MeSH terms

  • Animals
  • Fear*
  • Female
  • Locomotion*
  • Male