Recently described neoplasms of the sinonasal tract

Semin Diagn Pathol. 2016 Mar;33(2):62-70. doi: 10.1053/j.semdp.2015.12.001. Epub 2015 Dec 23.


Surgical pathology of the sinonasal region (i.e., nasal cavity and the paranasal sinuses) is notoriously difficult, due in part to the remarkable diversity of neoplasms that may be encountered in this area. In addition, a number of neoplasms have been only recently described in the sinonasal tract, further compounding the difficulty for pathologists who are not yet familiar with them. This manuscript will review the clinicopathologic features of some of the recently described sinonasal tumor types: NUT midline carcinoma, HPV-related carcinoma with adenoid cystic-like features, SMARCB1 (INI-1) deficient sinonasal carcinoma, biphenotypic sinonasal sarcoma, and adamantinoma-like Ewing family tumor.

Keywords: Adamantinoma-like Ewing family tumor; Biphenotypic sinonasal sarcoma; HPV-related carcinoma with adenoid cystic-like features; NUT midline carcinoma; SMARCB1 (INI-1) deficient sinonasal carcinoma.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • Humans
  • Immunohistochemistry
  • Nasal Cavity / chemistry
  • Nasal Cavity / pathology*
  • Nasal Cavity / virology
  • Nose Neoplasms / chemistry
  • Nose Neoplasms / classification
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / virology
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / pathology
  • Papillomavirus Infections / virology
  • Paranasal Sinus Neoplasms / chemistry
  • Paranasal Sinus Neoplasms / classification
  • Paranasal Sinus Neoplasms / pathology*
  • Paranasal Sinus Neoplasms / virology
  • Prognosis
  • Risk Factors


  • Biomarkers, Tumor