Inflammaging and cardiovascular disease: Management by medicinal plants

Phytomedicine. 2016 Oct 15;23(11):1119-26. doi: 10.1016/j.phymed.2015.11.004. Epub 2015 Dec 3.


Background: In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of inflammatory diseases. These conditions in the elderly people cause appearance of a phenomenon which has been denoted as "inflammaging". Understanding the pathogenesis and finding new methods for management of inflammaging are essential.

Purpose: In this paper we tried not only to explain inflammaging and its treatments with concentrating on medical plants but to collect a sufficient collection of anti-inflammatory plants with focusing on their mechanism of action.

Method: In this review paper, by searching in indexing cites, desired articles were obtained since 1995 by using keywords of inflammation, inflammaging, inflammation pathophysiology, free radicals and inflammation, aging inflammation, inflammatory disease, and plants or herbal medicine in inflammation.

Sections: In advanced age the generation of free radicals increases in cardiovascular system. Pathological inflammation is also associated with production of excess free radicals More importantly, chronic inflammation makes aged people susceptible to age-related diseases. Some medicinal plants have been shown promising results in inhibition of inflammaging. Some other sections such as inflammation and inflammaging in cardiovascular diseases, oxidative stress in cardiovascular complications, prevention and treatment strategies are presented.

Conclusion: The results of published papers show that the symptoms of several inflammatory diseases can be inhibited or treated by active ingredients from medicinal plants.

Keywords: Aging; Anti-inflammatory drugs; Cardiovascular disease; Inflammaging; Inflammation; Medicinal plants.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / physiology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antioxidants / pharmacology
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / physiopathology
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / etiology*
  • Inflammation / prevention & control
  • Oxidative Stress / drug effects
  • Plants, Medicinal*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants