Gastric emptying and gastro-oesophageal reflux in children with cystic fibrosis

J Cyst Fibros. 2016 Jul;15(4):540-7. doi: 10.1016/j.jcf.2015.12.015. Epub 2016 Jan 8.


Background: Gastro-oesophageal reflux (GOR) is common in patients with cystic fibrosis (CF). The aim of this study was to investigate the relationship between gastric emptying (GE) and GOR in children with CF.

Methods: Multichannel intraluminal impedance-pH monitoring (MII-pH) to measure GOR and GE breath test (GEBT) to measure GE were performed in 28 children with symptoms suggestive for GOR disease (GORD) (group 1). GEBT was performed in another 28 children with/without GOR symptoms who agreed to undergo GEBT but not MII-pH (group 2).

Results: In group 1, we found increased acid GOR (AGOR) in 46.4% and delayed GE (DGE) in 21.4% but no relationship between increased AGOR and DGE. There was no DGE in group 2. We found DGE in 10.7% and rapid GE in 12.5% of the whole group.

Conclusions: Almost half of the children with CF and symptoms suggestive for GORD have increased AGOR and almost a quarter has DGE. However, there was no relation between GOR and GE.

Keywords: (13)C-gastric emptying breath test; Children; Cystic fibrosis; Gastric emptying; Gastro-oesophageal reflux; Multichannel intraluminal impedance-pH monitoring.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Belgium
  • Breath Tests / methods
  • Child
  • Child, Preschool
  • Cystic Fibrosis* / complications
  • Cystic Fibrosis* / physiopathology
  • Esophageal pH Monitoring / methods
  • Female
  • Gastric Acidity Determination
  • Gastric Emptying*
  • Gastroesophageal Reflux* / diagnosis
  • Gastroesophageal Reflux* / etiology
  • Gastroesophageal Reflux* / physiopathology
  • Humans
  • Hydrogen-Ion Concentration*
  • Infant
  • Male
  • Prospective Studies
  • Statistics as Topic