Effect of Spirulina maxima Supplementation on Calcium, Magnesium, Iron, and Zinc Status in Obese Patients with Treated Hypertension

Biol Trace Elem Res. 2016 Sep;173(1):1-6. doi: 10.1007/s12011-016-0623-5. Epub 2016 Jan 16.


The effects of Spirulina maxima supplementation on calcium, magnesium, iron, and zinc status were studied in a double-blind placebo-controlled trial of 50 obese subjects with treated hypertension, each randomized to receive 2 g of spirulina or a placebo daily for 3 months. At baseline and after treatment, the calcium, magnesium, iron, and zinc concentration in plasma was assessed. It was found that 3 months of S. maxima supplementation resulted in a significant decrease in the iron level in the plasma of obese patients. In conclusion, this is the first clinical study on the influence of spirulina supplementation on mineral status in obese patients with hypertension. Spirulina supplementation affects the iron status of obese Caucasians with well-treated hypertension.

Keywords: Minerals; Obesity; Randomized trial; Spirulina; Treated hypertension.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Calcium / blood*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension* / blood
  • Hypertension* / complications
  • Hypertension* / diet therapy
  • Iron / blood*
  • Magnesium / blood*
  • Male
  • Middle Aged
  • Obesity* / blood
  • Obesity* / complications
  • Obesity* / diet therapy
  • Spirulina*
  • Zinc / blood*


  • Iron
  • Magnesium
  • Zinc
  • Calcium