Bisphenol A, Hypertension, and Cardiovascular Diseases: Epidemiological, Laboratory, and Clinical Trial Evidence

Curr Hypertens Rep. 2016 Feb;18(2):11. doi: 10.1007/s11906-015-0617-2.


Bisphenol A (BPA) exposure has become one of the most common environmental chemical exposures in humans. There is growing evidence regarding an association between BPA exposure, hypertension, and cardiovascular diseases (CVD). If BPA exposure is indeed associated with raised blood pressure and CVD, it would be a major public health problem. Therefore, we reviewed the epidemiological, laboratory, and clinical trial evidence for an association between BPA exposure, CVD, and hypertension, and discussed the possible mechanisms in this article. Cross-sectional studies in various ethnicities suggested a possible association between BPA exposure and hypertension; this association was supported by a panel study and a randomized clinical trial. Despite the discordance among cross-sectional studies about an association between BPA exposure and CVD, a longitudinal study shows that BPA exposure is a risk factor for CVD. The effects of BPA exposure such as endocrinal disturbance, induction of oxidative stress and inflammation, epigenetic change, and links with other chronic diseases may highlight a possible mechanism between BPA exposure, CVD, and hypertension. To clarify the causal relationship, well-designed studies are needed in the future.

Keywords: Bisphenol A; Cardiovascular diseases; Clinical trial; Epidemiology; Hypertension; Mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzhydryl Compounds / pharmacology*
  • Cardiovascular Diseases* / epidemiology
  • Clinical Trials as Topic
  • Humans
  • Hypertension* / epidemiology
  • Oxidative Stress
  • Phenols / pharmacology*
  • Risk Factors


  • Benzhydryl Compounds
  • Phenols
  • bisphenol A