Double blind study of a valerian preparation

Pharmacol Biochem Behav. 1989 Apr;32(4):1065-6. doi: 10.1016/0091-3057(89)90082-8.


Valerian root contains two substances of special pharmacological interest--valepotriates and sesquiterpenes. The former, which has been used for standardization of the drug, is cytotoxic. The latter has no such effect. Both have sedative effects. A double blind test has been carried out on a preparation (VALERINA NATT) containing primarily sesquiterpenes. When compared with placebo it showed a good and significant effect on poor sleep (p less than 0.001). Forty-four percent reported perfect sleep and 89% reported improved sleep from the preparation. No side effects were observed.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Compounding
  • Female
  • Humans
  • Iridoids*
  • Male
  • Middle Aged
  • Plant Extracts / pharmacology
  • Plants, Medicinal*
  • Pyrans / pharmacology*
  • Sesquiterpenes / analysis
  • Sesquiterpenes / pharmacology
  • Sleep / drug effects*
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Valerian*


  • Iridoids
  • Plant Extracts
  • Pyrans
  • Sesquiterpenes
  • valtrates (combination)