Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2016 Mar;30(2):318-22.
doi: 10.1016/j.jdiacomp.2015.11.009. Epub 2015 Nov 17.

Maggot Debridement Therapy Promotes Diabetic Foot Wound Healing by Up-Regulating Endothelial Cell Activity

Affiliations
Randomized Controlled Trial

Maggot Debridement Therapy Promotes Diabetic Foot Wound Healing by Up-Regulating Endothelial Cell Activity

Xinjuan Sun et al. J Diabetes Complications. .

Abstract

To determine the role of maggot debridement therapy (MDT) on diabetic foot wound healing, we compared growth related factors in wounds before and after treatment. Furthermore, we utilized human umbilical vein endothelial cells (HUVECs) to explore responses to maggot excretions/secretions on markers of angiogenesis and proliferation. The results showed that there was neo-granulation and angiogenesis in diabetic foot wounds after MDT. Moreover, significant elevation in CD34 and CD68 levels was also observed in treated wounds. In vitro, ES increased HUVEC proliferation, improved tube formation, and increased expression of vascular endothelial growth factor receptor 2 in a dose dependent manner. These results demonstrate that MDT and maggot ES can promote diabetic foot wound healing by up-regulating endothelial cell activity.

Keywords: Angiogenesis; Diabetic foot ulcers; HUVEC; Maggot debridement therapy; Wound healing.

Similar articles

See all similar articles

Cited by 4 articles

Publication types

MeSH terms

Substances

LinkOut - more resources

Feedback