Impact of Oxygenation Status on 18F-FDG Uptake in Solid Tumors

Adv Exp Med Biol. 2016;876:201-207. doi: 10.1007/978-1-4939-3023-4_25.

Abstract

The influence of changes in tumor oxygenation (monitored by EPR oximetry) on the uptake of 18F-FDG tracer was evaluated using micro-PET in two different human tumor models. The 18F-FDG uptake was higher in hypoxic tumors compared to tumors that present a pO2 value larger than 10 mmHg.

Keywords: 18F-FDG; Carbogen; EPR; PET; Tumor oxygenation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Electron Spin Resonance Spectroscopy
  • Fluorodeoxyglucose F18*
  • Humans
  • Mice
  • Neoplasms / metabolism*
  • Oxygen / metabolism*
  • Positron-Emission Tomography

Substances

  • Fluorodeoxyglucose F18
  • Oxygen