Akirin2 expression in response to vaccine-induced immunity in chicken

Genet Mol Res. 2015 Dec 21;14(4):17489-95. doi: 10.4238/2015.December.21.20.


Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during the various stages of increase in Newcastle disease virus antibody titer. The results revealed that akirin2 expression was significantly higher in the liver (P < 0.01) and bursa (P < 0.05) of vaccinated chicken 7 and 14 days post-immunization, respectively. These results could serve as a foundation for further studies on the functions of akirin2 in immune response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / genetics
  • Antibodies, Viral / immunology
  • Chickens
  • Cloning, Molecular
  • Immunity / drug effects
  • Immunity, Innate / genetics*
  • Repressor Proteins / biosynthesis*
  • Repressor Proteins / genetics
  • Vaccines / genetics*
  • Vaccines / immunology
  • Zinc Fingers / genetics*


  • Antibodies, Viral
  • Repressor Proteins
  • Vaccines