Donor ABCB1 3435 C>T genetic polymorphisms influence early renal function in kidney transplant recipients treated with tacrolimus

Pharmacogenomics. 2016 Feb;17(3):249-57. doi: 10.2217/pgs.15.165. Epub 2016 Jan 19.

Abstract

Aim: Determine the effect of genetic variants of donors and recipients on early renal function and tacrolimus pharmacokinetics in kidney transplant recipients.

Patients & methods: We measured CYP3A5 (6986A>G), ABCB1 (3435C>T, 2677G>T/A, 1236C>T) genetic polymorphisms in 120 renal transplant recipients and donors by high-resolution melting curve analysis. The renal function and tacrolimus trough concentrations were analyzed.

Results: The genotype of CYP3A5 (6986A>G) in recipients showed strong influence on tacrolimus pharmacokinetics. The ABCB1 3435 CC genotype in donor was significantly associated with lower estimated glomerular filtration in recipients within 1 month (p < 0.05) and correlated with delayed creatinine recovery (p = 0.007).

Conclusions: ABCB1 3435 CC genotype in donor influences early renal function and creatinine recovery in tacrolimus-treated kidney transplant recipients.

Keywords: ABCB1; CYP3A5; kidney transplantation; pharmacokinetics; renal function; tacrolimus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / genetics
  • Adult
  • Creatinine / blood
  • Cytochrome P-450 CYP3A / genetics
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Immunosuppressive Agents / pharmacokinetics*
  • Kidney / drug effects*
  • Kidney / physiopathology
  • Kidney Transplantation*
  • Living Donors*
  • Male
  • Polymorphism, Single Nucleotide
  • Tacrolimus / pharmacokinetics*

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • Immunosuppressive Agents
  • Creatinine
  • Cytochrome P-450 CYP3A
  • Tacrolimus