Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation

Clin Infect Dis. 2016 Apr 1;62(7):951-3. doi: 10.1093/cid/ciw020. Epub 2016 Jan 19.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candidiasis, Chronic Mucocutaneous / drug therapy*
  • Candidiasis, Chronic Mucocutaneous / immunology
  • Candidiasis, Chronic Mucocutaneous / pathology
  • Humans
  • Interleukin-17 / blood
  • Interleukin-17 / genetics*
  • Interleukin-17 / metabolism
  • Male
  • Mutation
  • Pyrazoles / therapeutic use*
  • STAT1 Transcription Factor / blood
  • STAT1 Transcription Factor / genetics*
  • STAT1 Transcription Factor / metabolism
  • Tongue / pathology

Substances

  • INCB018424
  • Interleukin-17
  • Pyrazoles
  • STAT1 Transcription Factor
  • STAT1 protein, human