Anxiolytic Effect of Citrus aurantium L. on Patients with Chronic Myeloid Leukemia

Phytother Res. 2016 Apr;30(4):613-7. doi: 10.1002/ptr.5566. Epub 2016 Jan 20.


The bone marrow aspiration procedure is used in hematological diseases and consists of a painful, invasive procedure causing anxiety-associated symptoms. The present study assessed the effect of Citrus aurantium L. essential oil on the treatment of anxiety, in the moment that precedes the collection of medullary material in patients with chronic myeloid leukemia (CML). Volunteers from both sexes were divided into groups receiving either the C. aurantium essential oil through inhalation, diazepam (10 mg), or the placebo. The evaluation was performed through psychometric scales [State-Trait Anxiety Inventory (STAI)] and physiological measurements (blood pressure and cardiac and respiratory frequency). Inhalation of C. aurantium was associated with a decrease in the STAI-S scores, suggesting an anxiolytic effect. In support of these results, a change in all the physiological measurements was observed in the group exposed to C. aurantium. In the diazepam group, only the diastolic pressure decreased, and no effect was observed in the placebo group. Therefore, the results showed that C. aurantium exhibits an anxiolytic effect and reduces the signs and symptoms associated with anxiety in patients with CML.

Keywords: Citrus aurantium L; anxiety; chronic myeloid leukemia; essential oil; via inhalation.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Adult
  • Anti-Anxiety Agents / therapeutic use*
  • Anxiety / drug therapy*
  • Blood Pressure
  • Citrus / chemistry*
  • Diazepam / therapeutic use
  • Humans
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / psychology*
  • Middle Aged
  • Odorants
  • Oils, Volatile / chemistry
  • Oils, Volatile / therapeutic use*
  • Plant Extracts / therapeutic use


  • Anti-Anxiety Agents
  • Oils, Volatile
  • Plant Extracts
  • Diazepam