Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

doi:10.1007/s13197-015-2048-0

. 2016 Jan;53(1):581-90.

doi: 10.1007/s13197-015-2048-0. Epub 2015 Oct 1.

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Kozo Nakamura¹, Masahiro Koyama², Ryuya Ishida³, Takashi Kitahara⁴, Takero Nakajima⁵, Toshifumi Aoyama⁵

Affiliations

¹ Institute of Agriculture, Academic Assembly, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan ; Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan ; Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
² Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
³ Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
⁴ Saladcosmo Co., Ltd, 1-15 Sentanbayashi, Nakatsugawa, Gifu 509-9131 Japan.
⁵ Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621 Japan.

PMID: 26787977
PMCID: PMC4711472
DOI: 10.1007/s13197-015-2048-0

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Kozo Nakamura et al. J Food Sci Technol. 2016 Jan.

. 2016 Jan;53(1):581-90.

doi: 10.1007/s13197-015-2048-0. Epub 2015 Oct 1.

Authors

Kozo Nakamura¹, Masahiro Koyama², Ryuya Ishida³, Takashi Kitahara⁴, Takero Nakajima⁵, Toshifumi Aoyama⁵

Affiliations

¹ Institute of Agriculture, Academic Assembly, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan ; Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan ; Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
² Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
³ Department of Bioscience and Biotechnology, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-Village, Nagano, 399-4598 Japan.
⁴ Saladcosmo Co., Ltd, 1-15 Sentanbayashi, Nakatsugawa, Gifu 509-9131 Japan.
⁵ Department of Metabolic Regulation, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621 Japan.

PMID: 26787977
PMCID: PMC4711472
DOI: 10.1007/s13197-015-2048-0

Abstract

Hypertension, hyperlipidemia, and diabetes are important precursors of cardiovascular disease. Here, we evaluated the antihypertensive, antihyperlipidemic, and antidiabetic potential of five types of sprouts in fructose-loaded spontaneously hypertensive rats (SHRs). Powdered sprouts (PSs) were produced from mung bean, broccoli, radish, and buckwheat sprouts and germinated soybeans by lyophilization. The PSs were analyzed for nutritional composition and bioactive agents (γ-aminobutyric acid [GABA], coenzyme Q10 [CoQ10], rutin, and myo-inositol-1,2,3,4,5,6-hexakisphosphate [IP6]) and functionally tested in SHRs given water containing 25 % fructose and diets containing 30 % PS for 46 days. All PSs were nutritionally rich in protein and dietary fiber. CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively. Mung bean, broccoli, and buckwheat PSs caused significant reductions in heart rates and/or serum triglycerides. Mung bean PS also significantly reduced serum total cholesterol. These data supported the antihypertensive and antihyperlipidemic potential of mung bean, broccoli, and buckwheat sprouts.

Keywords: Antihyperlipidemia; Antihypertension; Broccoli; Buckwheat; Fructose-loaded SHR; Mung bean; Sprouts.

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References

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[1] Ajay M, Gilani AU, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74(5):603–612. doi: 10.1016/j.lfs.2003.06.039. - DOI - PubMed

[2] Ajay M, Gilani AU, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74(5):603–612. doi: 10.1016/j.lfs.2003.06.039. - DOI - PubMed

[3] Anderson JW, Randles KM, Kendall CW, et al. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J Am Coll Nutr. 2004;23:5–17. doi: 10.1080/07315724.2004.10719338. - DOI - PubMed

[4] Anderson JW, Randles KM, Kendall CW, et al. Carbohydrate and fiber recommendations for individuals with diabetes: a quantitative assessment and meta-analysis of the evidence. J Am Coll Nutr. 2004;23:5–17. doi: 10.1080/07315724.2004.10719338. - DOI - PubMed

[5] Aoyama T, Peters JM, Iritani N, et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) J Biol Chem. 1998;273:5678–5684. doi: 10.1074/jbc.273.10.5678. - DOI - PubMed

[6] Aoyama T, Peters JM, Iritani N, et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα) J Biol Chem. 1998;273:5678–5684. doi: 10.1074/jbc.273.10.5678. - DOI - PubMed

[7] Bouche N, Fait A, Bouchez D, et al. Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003;100(11):6843–6848. doi: 10.1073/pnas.1037532100. - DOI - PMC - PubMed

[8] Bouche N, Fait A, Bouchez D, et al. Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants. Proc Natl Acad Sci U S A. 2003;100(11):6843–6848. doi: 10.1073/pnas.1037532100. - DOI - PMC - PubMed

[9] Brownlee IA. The physiological roles of dietary fibre. Food Hydrocoll. 2011;25(2):238–250. doi: 10.1016/j.foodhyd.2009.11.013. - DOI

[10] Brownlee IA. The physiological roles of dietary fibre. Food Hydrocoll. 2011;25(2):238–250. doi: 10.1016/j.foodhyd.2009.11.013. - DOI

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Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Affiliations

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

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Abstract

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