HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

Ann Chahroudi; Guido Silvestri

doi:10.1016/j.immuni.2015.12.016

HIV and Tfh Cells: Circulating New Ideas to Identify and Protect

Immunity. 2016 Jan 19;44(1):16-18. doi: 10.1016/j.immuni.2015.12.016.

Authors

Ann Chahroudi¹, Guido Silvestri²

Affiliations

¹ Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
² Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA; Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA. Electronic address: gsilves@emory.edu.

PMID: 26789919
DOI: 10.1016/j.immuni.2015.12.016

Abstract

T follicular helper (Tfh) cells provide crucial support to antigen-specific B cells. In this issue of Immunity, Schultz et al. (2016) report that circulating IL-21-producing CD4(+) T cells are phenotypically, transcriptionally, and functionally similar to lymphoid Tfh cells and that such HIV-specific Tfh cells were increased in RV144 trial vaccine recipients.

Publication types

Comment

MeSH terms

HIV Infections / immunology*
Humans
Interleukins / immunology*
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Helper-Inducer / immunology*

Substances

Interleukins