Marriage and fertility in long-term survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma

Int J Clin Oncol. 2016 Aug;21(4):801-807. doi: 10.1007/s10147-016-0948-2. Epub 2016 Jan 20.


Purpose: We investigated the marital status and the presence or absence of children in survivors of childhood, adolescent and young adult (AYA) high-grade sarcoma and examined the influence of these factors on the quality of life (QOL) of these survivors.

Methods: Thirty-eight survivors of childhood and AYA high-grade sarcoma (18 males, 20 females) participated in a questionnaire survey on marital status and presence or absence of children, as well as on the health-related QOL (HR-QOL), using the Short Form 36 Health Survey. Diagnoses among these survivors were osteosarcoma (28 participants), Ewing's sarcoma (4 participants), synovial sarcoma (4 participants) and others (2 participants).

Results: Of the 18 males who participated in the survey, eight (44.4 %) were married, of whom five (62.5 %) had children. Fifteen (75.0 %) of the 20 females were married, of whom 14 (93.3 %) had children. The proportions of surviving male patients who were married and who had children, respectively, were lower than those of surviving female patients. The proportion of ifosfamide-treated men with children was significantly lower than that of non-ifosfamide-treated men (p = 0.018). With respect to the relationship between marital status and HR-QOL, the scores for the vitality and mental health domains of the SF-36 of survivors who were married were significantly higher than those of unmarried survivors.

Conclusions: The results of our questionnaire survey reveal that among the male survivors of high-grade sarcoma, the proportions of those who were married and of those with children were lower than those of female survivors, suggesting that strategies providing support for marriage and child-rearing may be necessary for the male survivor group. In the married group, mental QOL was high.

Keywords: Adolescent and young adult; Fertility; Marriage; Quality of life; Sarcoma.

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Agents, Alkylating / administration & dosage
  • Antineoplastic Agents, Alkylating / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Neoplasms / drug therapy*
  • Bone Neoplasms / epidemiology*
  • Child
  • Female
  • Fertility* / drug effects
  • Health Surveys
  • Humans
  • Ifosfamide / administration & dosage
  • Ifosfamide / adverse effects*
  • Male
  • Marital Status / statistics & numerical data*
  • Marriage / statistics & numerical data
  • Middle Aged
  • Osteosarcoma / drug therapy
  • Osteosarcoma / epidemiology
  • Quality of Life
  • Sarcoma, Ewing / drug therapy
  • Sarcoma, Ewing / epidemiology
  • Sarcoma, Synovial / drug therapy
  • Sarcoma, Synovial / epidemiology
  • Surveys and Questionnaires
  • Survivors / statistics & numerical data*
  • Young Adult


  • Antineoplastic Agents, Alkylating
  • Ifosfamide