The XEN of reprogramming

Cell Res. 2016 Feb;26(2):147-8. doi: 10.1038/cr.2016.9. Epub 2016 Jan 22.


Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by Yamanaka factors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cellular Reprogramming Techniques*
  • Pluripotent Stem Cells / cytology*