Postnatal glucocorticoid-induced hypomyelination, gliosis, and neurologic deficits are dose-dependent, preparation-specific, and reversible

Exp Neurol. 2016 Apr:278:1-3. doi: 10.1016/j.expneurol.2016.01.012. Epub 2016 Jan 18.

Authors

Shadi N Malaeb¹, Barbara S Stonestreet²

Affiliations

¹ Department of Pediatrics, St. Christopher's Hospital for Children, Drexel University College of Medicine, 245 North 15th Street, New College Building, Room7410, Mail Stop 1029, Philadelphia, PA 19102, USA.
² The Alpert Medical School of Brown University, Department of Pediatrics, Women & Infants Hospital of Rhode Island, 101 Dudley Street, Providence, RI 02905, USA.

PMID: 26795086
DOI: 10.1016/j.expneurol.2016.01.012

No abstract available

MeSH terms

Animals
Animals, Newborn
Charcot-Marie-Tooth Disease / chemically induced*
Disease Models, Animal
Dose-Response Relationship, Drug
Gliosis / chemically induced*
Glucocorticoids / toxicity*
Nervous System Diseases / chemically induced*

Substances

Glucocorticoids

Supplementary concepts

Charcot-Marie-Tooth disease, Type 4E