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. 2016;568:661-79.
doi: 10.1016/bs.mie.2015.09.020. Epub 2015 Nov 3.

Intermediate Filaments in Caenorhabditis Elegans

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Intermediate Filaments in Caenorhabditis Elegans

Noam Zuela et al. Methods Enzymol. .

Abstract

More than 70 different genes in humans and 12 different genes in Caenorhabditis elegans encode the superfamily of intermediate filament (IF) proteins. In C. elegans, similar to humans, these proteins are expressed in a cell- and tissue-specific manner, can assemble into heteropolymers and into 5-10nm wide filaments that account for the principal structural elements at the nuclear periphery, nucleoplasm, and cytoplasm. At least 5 of the 11 cytoplasmic IFs, as well as the nuclear IF, lamin, are essential. In this chapter, we will include a short review of our current knowledge of both cytoplasmic and nuclear IFs in C. elegans and will describe techniques used for their analyses.

Keywords: Animal development; Cell mechanics; Filament assembly; Lamin.

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