Small Immunoglobulin Domain Proteins at Synapses and the Maintenance of Neuronal Features

Neuron. 2016 Jan 20;89(2):239-41. doi: 10.1016/j.neuron.2016.01.005.


The integrity of neural circuits must be maintained throughout the lifetime of an organism. In this issue of Neuron, Cherra and Jin (2016) characterize a small, two-Ig domain protein, ZIG-10, and its role in maintaining synaptic density in a specific set of C. elegans neurons.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins / metabolism*
  • Epidermis / metabolism*
  • Humans
  • Immunoglobulins / metabolism*
  • Neurons / metabolism*
  • Synapses / metabolism*


  • Caenorhabditis elegans Proteins
  • Immunoglobulins