Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 470 (3), 650-656

Activation of the Phosphatidylinositol 3-kinase/Akt Pathway by Viral Interferon Regulatory Factor 2 of Kaposi's Sarcoma-Associated Herpesvirus

Affiliations

Activation of the Phosphatidylinositol 3-kinase/Akt Pathway by Viral Interferon Regulatory Factor 2 of Kaposi's Sarcoma-Associated Herpesvirus

Yejin Kim et al. Biochem Biophys Res Commun.

Abstract

Kaposi's sarcoma-associated herpesvirus encodes several genes with sequence homology to cellular interferon regulatory factors. Among these, vIRF2 encoded by ORF K11.1 (short form) or K11 (full-length) participates in caspase-3-mediated inactivation of cellular IRF3 and slightly inhibits caspase-3 activity. Here, we have demonstrated that vIRF2 attenuates the transcriptional activity of forkhead box O3A protein via activation of the PI3K/Akt phosphatidylinositol 3-kinase/Akt pathway, inhibiting FOXO3A-mediated caspase-3 cleavage. Based on the collective findings, we suggest that vIRF2 acts as an activator in PI3K/Akt pathway.

Keywords: Caspase-3; FOXO3A; KSHV; PI3K/Akt pathway; vIRF2.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

Publication types

LinkOut - more resources

Feedback