What do we know about sulforaphane protection against photoaging?

J Cosmet Dermatol. 2016 Mar;15(1):72-7. doi: 10.1111/jocd.12176. Epub 2016 Jan 22.

Abstract

Sulforaphane (SFN), a natural compound occurring in cruciferous vegetables, has been known for years as a chemopreventive agent against many types of cancer. Recently, it has been investigated as an antioxidant and anti-aging agent, and interesting conclusions have been made over the last decade. SFN demonstrated protective effects against ultraviolet (UV)-induced skin damage through several mechanisms of action, for example, decrease of reactive oxygen species production, inhibition of matrix metalloproteinase expression, and induction of phase 2 enzymes. SFN used as a protective agent against UV damage is a whole new matter, and it seems to be a very promising ingredient in upcoming anti-aging drugs and cosmetics.

Keywords: aging; skin; sulforaphane; ultraviolet.

Publication types

  • Review

MeSH terms

  • Anticarcinogenic Agents / pharmacology*
  • Humans
  • Isothiocyanates / pharmacology*
  • Kelch-Like ECH-Associated Protein 1 / drug effects
  • Matrix Metalloproteinase 1 / drug effects
  • Matrix Metalloproteinase 3 / drug effects
  • NF-E2-Related Factor 2 / drug effects
  • NF-kappa B / drug effects
  • Radiation-Protective Agents / pharmacology
  • Signal Transduction / drug effects*
  • Skin / drug effects*
  • Skin / radiation effects
  • Skin Aging / drug effects*
  • Skin Aging / radiation effects
  • Transcription Factor AP-1 / drug effects
  • Transcription Factor AP-1 / radiation effects
  • Ultraviolet Rays / adverse effects

Substances

  • Anticarcinogenic Agents
  • Isothiocyanates
  • KEAP1 protein, human
  • Kelch-Like ECH-Associated Protein 1
  • NF-E2-Related Factor 2
  • NF-kappa B
  • NFE2L2 protein, human
  • Radiation-Protective Agents
  • Transcription Factor AP-1
  • Matrix Metalloproteinase 3
  • Matrix Metalloproteinase 1
  • sulforaphane