Abstract
HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection. Over the years, intensive research has led to a variety of approved protease inhibitors for the treatment of HIV/AIDS. In this review, we outline current drug design and medicinal chemistry efforts toward the development of next-generation protease inhibitors beyond the currently approved drugs.
Publication types
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Review
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Research Support, Non-U.S. Gov't
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Research Support, N.I.H., Extramural
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy*
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Drug Design
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HIV Infections / drug therapy*
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HIV Protease / metabolism*
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HIV Protease Inhibitors / chemical synthesis
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HIV Protease Inhibitors / chemistry
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HIV Protease Inhibitors / pharmacology*
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HIV-1 / drug effects
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Humans
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Molecular Structure
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Structure-Activity Relationship
Substances
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HIV Protease Inhibitors
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HIV Protease
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p16 protease, Human immunodeficiency virus 1