Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)

J Magn Reson Imaging. 2016 Aug;44(2):426-32. doi: 10.1002/jmri.25144. Epub 2016 Jan 22.


Purpose: To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM).

Materials and methods: The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change.

Results: Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001).

Conclusion: MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.

Keywords: gadolinium enhancement; longitudinal change; magnetic resonance imaging; multiple sclerosis; quantitative susceptibility mapping (QSM).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aging / pathology*
  • Algorithms*
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Disease Progression
  • Early Diagnosis
  • Female
  • Humans
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods
  • Longitudinal Studies
  • Magnetic Fields
  • Male
  • Multiple Sclerosis / diagnostic imaging
  • Multiple Sclerosis / pathology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*