Cytoplasmic tail domain of glycoprotein B is essential for HHV-6 infection

Virology. 2016 Mar;490:1-5. doi: 10.1016/j.virol.2015.12.018. Epub 2016 Jan 21.


Human herpesvirus 6 (HHV-6) glycoprotein B (gB) is an abundantly expressed viral glycoprotein required for viral entry and cell fusion, and is highly conserved among herpesviruses. The present study examined the function of HHV-6 gB cytoplasmic tail domain (CTD). A gB CTD deletion mutant was constructed which, in contrast to its revertant, could not be reconstituted. Moreover, deletion of gB cytoplasmic tail impaired the intracellular transport of gB protein to the trans-Golgi network (TGN). Taken together, these results suggest that gB CTD is critical for HHV-6 propagation and important for intracellular transportation.

Keywords: Cytoplasmic tail domain; Glycoprotein B; HHV-6; Intracellular transport.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Herpesvirus 6, Human / chemistry
  • Herpesvirus 6, Human / genetics
  • Herpesvirus 6, Human / growth & development
  • Herpesvirus 6, Human / metabolism*
  • Humans
  • Protein Structure, Tertiary
  • Roseolovirus Infections / virology*
  • Viral Envelope Proteins / chemistry*
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / metabolism*
  • trans-Golgi Network / virology


  • Viral Envelope Proteins
  • glycoprotein B, human herpesvirus-6