microRNAs in Psoriasis

J Invest Dermatol. 2016 Feb;136(2):365-371. doi: 10.1038/JID.2015.409.


Psoriasis is a chronic inflammatory skin condition resulting from a complex interplay among the immune system, keratinocytes, susceptibility genes, and environmental factors. However, the pathogenesis of psoriasis is not completely elucidated. microRNAs represent a promising class of small, noncoding RNA molecules that function to regulate gene expression. Although microRNA research in psoriasis and dermatology is still relatively new, evidence is rapidly accumulating for the role of microRNAs in the pathogenesis of psoriasis and other chronic inflammatory conditions. In this article, we present a comprehensive review of what is known about microRNAs and their role in the pathogenesis of psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Psoriasis / genetics*
  • Psoriasis / physiopathology*
  • Sensitivity and Specificity


  • MicroRNAs