Guillain-Barre syndrome in a 7-month-old boy successfully applied plasma exchange

Transfus Apher Sci. 2016 Feb;54(1):139-43. doi: 10.1016/j.transci.2016.01.001. Epub 2016 Jan 12.


Despite being the most common cause of acute flaccid paralysis in children Guillain-Barré syndrome has a low incidence under 18 years old, and is even rarer under the age of 2. Established treatment regimens include intravenous immunoglobulin and plasma exchange in older children and adults. However very limited data are available for the efficacy and safety of plasma exchange in infants younger than 12 month-old. This article presents the experience of plasma exchange in the case of 7-month-old boy diagnosed with Guillain-Barré syndrome. A 7-month-old boy was referred to the pediatric intensive care unit with a 10-day history of progressive weakness, feeding difficulty and constipation. He was diagnosed with axonal Guillain-Barré syndrome on the basis of clinical and electromyographical findings. The patient recovered fully with intravenous immunoglobulin and plasma exchange. Plasma exchange may be a safe option in the treatment in infants with Guillain-Barré syndrome as young as 7-month-age.

Keywords: Children; Guillain–Barré syndrome; Intravenous immunoglobulin; Pediatric intensive care unit; Plasma exchange.

Publication types

  • Case Reports

MeSH terms

  • Guillain-Barre Syndrome / therapy*
  • Humans
  • Infant
  • Male
  • Plasma Exchange / methods*
  • Respiration, Artificial