XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Christina Piperi; Christos Adamopoulos; Athanasios G Papavassiliou

doi:10.1016/j.tem.2016.01.001

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Trends Endocrinol Metab. 2016 Mar;27(3):119-122. doi: 10.1016/j.tem.2016.01.001. Epub 2016 Jan 20.

Authors

Christina Piperi¹, Christos Adamopoulos¹, Athanasios G Papavassiliou²

Affiliations

¹ Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
² Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address: papavas@med.uoa.gr.

PMID: 26803729
DOI: 10.1016/j.tem.2016.01.001

Abstract

X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.

Keywords: X-box binding protein 1; glucose; lipogenesis; metabolic diseases; unfolded protein response.

MeSH terms

Animals
Drugs, Investigational / pharmacology
Drugs, Investigational / therapeutic use
Endoplasmic Reticulum Stress / drug effects
Endoribonucleases / antagonists & inhibitors
Endoribonucleases / chemistry
Endoribonucleases / genetics
Endoribonucleases / metabolism
Gene Expression Regulation* / drug effects
Glucagon / metabolism*
Glucose Metabolism Disorders / drug therapy
Glucose Metabolism Disorders / physiopathology
Humans
Hypoglycemic Agents / pharmacology
Hypoglycemic Agents / therapeutic use
Insulin / metabolism*
Insulin Secretion
Islets of Langerhans / metabolism
Islets of Langerhans / physiology*
Islets of Langerhans / physiopathology
Lipid Metabolism* / drug effects
Models, Biological*
Molecular Targeted Therapy
Protein Serine-Threonine Kinases / antagonists & inhibitors
Protein Serine-Threonine Kinases / chemistry
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism
Signal Transduction / drug effects
Unfolded Protein Response / drug effects
X-Box Binding Protein 1 / agonists
X-Box Binding Protein 1 / antagonists & inhibitors
X-Box Binding Protein 1 / genetics
X-Box Binding Protein 1 / metabolism*

Substances

Drugs, Investigational
Hypoglycemic Agents
Insulin
X-Box Binding Protein 1
XBP1 protein, human
Glucagon
ERN1 protein, human
Protein Serine-Threonine Kinases
Endoribonucleases