In-situ expression of Interleukin-18 and associated mediators in the human brain of sALS patients: Hypothesis for a role for immune-inflammatory mechanisms

Med Hypotheses. 2016 Jan;86:14-7. doi: 10.1016/j.mehy.2015.11.022. Epub 2015 Nov 26.


Recent studies reported over-expression of a cytokine (Interleukin (IL)-18) in the serum of sporadic amyotrophic lateral sclerosis (sALS) patients. Here, we report on the first-time detection of in-situ expression of activated IL-18 in the human brain in sALS patients. We also detected cerebral in-situ expression of key-molecules known to be closely related to the molecular network associated with the activation/secretion of IL-18 cytokine, namely, the receptor-interacting serine/threonine-protein kinase 3 (RIPK3 or RIP3), NOD-like receptor pyrin domain containing 3 (NLRP3)-inflammasome, and activated caspase-1. These findings suggest and allow to hypothesize that there might be a role for this cytokine network in molecular mechanisms associated with or implicated in the physiopathology of this neurodegenerative disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / immunology*
  • Brain / immunology*
  • Encephalitis / immunology*
  • Humans
  • Immunity, Innate / immunology
  • Inflammation Mediators / immunology*
  • Interleukin-18 / immunology*
  • Models, Immunological*
  • Models, Neurological


  • Inflammation Mediators
  • Interleukin-18