The Effect of Pomegranate Juice on Clinical Signs, Matrix Metalloproteinases and Antioxidant Status in Patients With Knee Osteoarthritis

J Sci Food Agric. 2016 Oct;96(13):4377-81. doi: 10.1002/jsfa.7647. Epub 2016 Feb 22.

Abstract

Background: Osteoarthritis (OA) is one of the commonest forms of musculoskeletal disorders that leads to joint degeneration and has a major impact on patients' quality of life. Experimental and in vitro studies have suggested the protective roles of pomegranate juice (PJ) as a rich antioxidant source for mitigating cartilage inflammation. In this interventional study, 38 patients with knee OA were randomly divided into two groups: PJ or control for 6 weeks to evaluate the effect of this intervention on clinical signs, inflammation and antioxidant status.

Results: Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention. The means of serum levels of matrix metalloproteinase (MMP)-13 was significantly decreased (P = 0.02) and glutathione peroxidase was increased in the intervention group compared with the control group after the study period (P = 0.02).

Conclusions: According to the findings of this clinical trial, PJ consumption can improve physical function and stiffness, decrease breakdown cartilage enzymes and increase antioxidant status in patients with knee OA. © 2016 Society of Chemical Industry.

Keywords: knee osteoarthritis; matrix metalloproteinases; pain; pomegranate.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / analysis
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antioxidants / administration & dosage
  • Antioxidants / analysis
  • Antioxidants / therapeutic use
  • Female
  • Follow-Up Studies
  • Fruit and Vegetable Juices* / analysis
  • Glutathione Peroxidase / blood*
  • Glutathione Peroxidase / chemistry
  • Humans
  • Iran
  • Knee Joint / immunology
  • Knee Joint / physiopathology*
  • Lythraceae* / chemistry
  • Male
  • Matrix Metalloproteinase 1 / blood
  • Matrix Metalloproteinase 1 / chemistry
  • Matrix Metalloproteinase 13 / blood*
  • Matrix Metalloproteinase 13 / chemistry
  • Middle Aged
  • Osteoarthritis, Knee / blood
  • Osteoarthritis, Knee / diet therapy*
  • Osteoarthritis, Knee / immunology
  • Osteoarthritis, Knee / physiopathology
  • Oxidative Stress*
  • Pain Measurement
  • Self Report
  • Severity of Illness Index

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Glutathione Peroxidase
  • MMP13 protein, human
  • Matrix Metalloproteinase 13
  • MMP1 protein, human
  • Matrix Metalloproteinase 1